Loyola University Chicago

Department of Chemistry and Biochemistry

Faculty & Staff

Becker, Daniel

Title/s: Professor

Office #: FH-217A

Phone: 773.508.3089

E-mail: dbecke3@luc.edu

External Webpage: http://www.beckerlabluc.com/


  • Ph.D. in Chemistry, Indiana University, Bloomington, IN
  • B.A. in Chemistry, Kalamazoo College, Kalamazoo, MI

Research Interests

‌‌‌‌Our research is focused on the design and synthesis of metalloenzyme inhibitors and also of serine protease and serine hydrolase inhibitors with antibiotic properties. In addition, we are interested in the synthesis and conformational dynamics of supramolecular scaffolds related to cyclotriveratrylene (CTV) with applications in host-guest chemistry. Other active research areas involve synthetic methodology including cascade reactions and metal-catalyzed functionalization reactions.

Becker research group

Selected Publications

Samuel R.S. Sarsah, Marlon R. Lutz, Jr., Kailyn Chichi Liu, Daniel P. Becker, “Metal-Free Tandem Beckmann-Electrophilic Aromatic Substitution Cascade Affording Diaryl Imines, Ketones, Amines and QuinazolinesTetrahedron Lett., 2015, 56, 5390–5392.

Zachary Osner, Richard Holz, and Daniel P. Becker, “An analytical method for detecting toxic metal cations using cyclotriveratrylene derivative capped gold nanoparticlesTetrahedron Lett., 2015, 56, 5419–5423.

Danuta M. Gillner, Daniel P. Becker, and Richard C. Holz, "Lysine Biosynthesis in Bacteria: A Metallodesuccinylase as a Potential Antimicrobial Target", Journal of Biological Inorganic Chemistry (JBIC) 2013, 18(2), 155-163.

Samuel R.S. Sarsah, Marlon R. Lutz Jr., Matthias Zeller, David S. Crumrine, and Daniel P. Becker, “Rearrangement of Cyclotriveratrylene (CTV) Diketone: 9,10-Diarylanthracenes with OLED ApplicationsJ. Org Chem. 2013, 78 2051-2058.

Andria M. Panagopoulos, Doug Steinman, Alexandra Goncharenko, Kyle Geary, Carlene Schleisman, Elizabeth Spaargaren, Matthias Zeller, and Daniel P. Becker, “Apparent Alkyl Transfer and Phenazine Formation via an Aryne Intermediate”, J. Org. Chem., 2013, 78, 3532−3540, Featured Article.

Ekaterina I. Filippova, Leigh A. Weston, Misty L. Kuhn2, Brett Geisslr3, Alexandra M. Gehrin1, Nicola Armoush, Chinessa T. Adkins, George Minasov, Ievgeniia Dubrovska, Ludmilla Shuvalova, James R. Winsor, Luke D. Lavis, Karla J. F. Satchell, Daniel P. Becker, Wayne F. Anderson, and R. Jeremy Johnson, “Large-scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysisJ. Biol. Chem., 2013, 288(15), 10522-10535.

Marlon R. Lutz Jr., Matthias Zeller, Samuel Sarsah, Artur Filipowicz, Hailey Wouters, and Daniel P. Becker, “Synthesis, Crystal Structure, and Rearrangements of ortho-Cyclophane Cyclotetraveratrylene (CTTV) Tetraketone”, Supramolecular Chemistry, 2012, 24, 803-809.

Othman A. Hamed, Arab El-Qisairi, Hanan Qaseer, Emad M. Hamed, Patrick M. Henry, and Daniel P. Becker, "Asymmetric a-Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex”, Tetrahedron Lett., 2012, 53, 10.1016/j.tetlet.2012.03.066.

Osner, Zachary; Nyamjav, Dorjderem; Holz, Richard; Becker, Daniel P.  Nanotechnology, 2011, 22, 275611.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Easton, Alan M.; Hockerman, Susan L.; Kiefer, James; Munie, Grace E.; Mathis, Karl J.; Li, Madeleine H.; Rico, Joseph G.; Villamil, Clara I.; Williams, Jennifer M. “MMP-13 Selective a-Sulfone Hydroxamates:  A Survey of P1’ Heterocyclic Amide Isosteres”   Bioorganic & Medicinal Chemistry Letters, 2011, 21 2820-2822.

Fobian, Yvette; Freskos, John N.; Barta, Thomas E.; Heintz, Robert; Kiefer, James R.; Mischke, Brent V.; Mullins, Patrick; Munie, Grace E.; Becker, Daniel P. “MMP-13 Selective a-Sulfone Hydroxamates Identification of selective P1’ Amides” Bioorganic & Medicinal Chemistry Letters, 2011, 21 2823-2825.

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell, Terri L. Boehm, Brian R. Bond, Jeffery Carroll, Chris P. Carron, Gary A. DeCrescenzo, Alan M. Easton, John Freskos, Chris L. Funckes-Shippy, Marcia Heron, Susan Hockerman, Susan Carol Howard, James R. Kiefer, Madeleine H. Li, Karl J. Mathis, Joseph J. McDonald, Pramod P. Mehta, Grace E. Munie, Teresa Sunyer, Craig A. Swearingen, Clara I. Villamil, Dean Welsch, Jennifer M. Williams, Jun Yao, Ying Yu “Orally-Active MMP-1 Sparing a-Tetrahydropyranyl and a-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular DiseaseJournal of Medicinal Chemistry, 2010 53 6653-6680.  Highlighted in SciBX: Science-Business eXchange September 2, 2010, Volume 3, number 34.

Hamed, Othman; Henry, Patrick; Becker, Daniel P. “Palladium(II)-Catalyzed Dicarboxymethylation of Chiral Allylic Alcohols:  Chirality Transfer Affording  Optically Active Diesters Containing Three Contiguous Chiral Centers“ Tetrahedron Lett., 2010, 51, 3514-3517.

Stephen A. Kolodziej, Susan L. Hockerman, Gary A. DeCrescenzo, Joseph J. McDonald, Debbie A. Mischke, Grace E. Munie, Theresa R. Fletcher, Nathan W. Stehle, Craig Swearingen and Daniel P. Becker “MMP-13 Selective Isonipecotamide alpha-Sulfone Hydroxamates” Bioorganic & Medicinal Chemistry Letters, 2010, 20 3561-3564. 

Stephen A. Kolodziej, Susan L. Hockerman, Terri L. Boehm,, Joseph G. Rico, Jeffery N. Carroll, Gary A. De Crescenzo, Joseph J. McDonald, Debbie A. Mischke, Grace E. Munie, Theresa R. Fletcher, Nathan W. Stehle, Craig Swearingen and Daniel P. Becker, “Orally Bioavailable Dual MMP-1/MMP-14 Sparing MMP-13 Selective alpha-Sulfone Hydroxamates” Bioorganic & Medicinal Chemistry Letters, 2010, 20 3557-3560. 

French, David; Lutz, Marlon R.; Lu, Chichi; Zeller, Matthias; Becker, Daniel P. “A Thermodynamic and Kinetic Characterization of the Solvent Dependence of the Saddle-Crown Equilibrium of Cyclotriveratrylene (CTV) Oxime,  J. Phys. Chem A., 2009, 113, 8258-8267. 

Gillner, Danuta; Nicola Armoush, Holz; Richard C.; and Becker, Daniel P. “Inhibitors of Bacterial N-Succinyl-L,L-diaminopimelic Acid Desuccinylase (DapE) and Demonstration of in vitro Antimicrobial ActivityBioorganic & Medicinal Chemistry Letters, 2009, 19, 6350-6352.

Zeller, Matthias; Lutz Jr., Marlon R.; Becker, Daniel P. “An aza-cyclophane stacked in racemic columnar assemblies:  Whole molecular disorder in a 2D solid solution“  Acta Cryst B: Structural Science 2009, 65(2), 223-229. PMID: 19299878

Lutz Jr., Marlon R.; Zeller, Matthias; Becker, Daniel P. "Beckmann Rearrangement of Cyclotriveratrylene (CTV) Oxime: Tandem Beckmann-Electrophilic AromaticAddition", Tetrahedron Letters 2008, 49, 5003-5005.

Armoush, Nicola; Kataria, Preeti; Becker, Daniel P. "Synthesis of Substituted 2-Amino-Cyclobutanones", Synthetic Communications 2008, 38 (11), 1679-1687.

Lutz Jr., Marlon R., French, David C., Rehage, Peter, & Becker, Daniel P. "Isolation of the saddle and crown conformers of cyclotriveratrylene (CTV) oxime", Tetrahedron Lett. 2007, 48, 6368-6371.