Each College and School at Loyola University Chicago has been established with a unique purpose and goal. There have been 13 Colleges and Schools at Loyola, 12 of which are still active.

• Arts and Sciences, College of (1870-)
• Arrupe College (2015-)
• School of Law (1908-)
• Stritch School of Medicine (1910-)
• School of Dentistry (1923- 1993)
• School of Social Work (1914-)
• The Graduate School (1925-)
• Niehoff School of Nursing (1935-)
• School of Business Administration (1922-)
• School of Education (1969-)
• School of Continuing and Professional Studies (1914-)
• School of Communication (2007-)
• School of Environmental Sustainability (2013-)