Hui Ye
Professor
Biomedical Engineering
Ph.D. 2005, Case Western Reserve University
Phone: 773.508.2720
Fax: 773.508.3646
E-mail: hye1@luc.edu
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RESEARCH INTERESTS
Our lab is interested in understanding the interactions between electromagnetic waves and neurons. More specifically, we investigate the biophysical and neurological mechanisms underlying electromagnetic stimulation to the nervous system, both in physiological and pathological conditions. The tools we use include computer simulation, in vivo and in vitro (patch clamp) electrophysiology, pharmacology, and imaging. There are two goals for this research. First, it will reveal the cellular and molecular mechanisms underlying the clinical treatment of neurological diseases with electromagnetic stimulations, such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS). Second, it will drive us to develop novel engineering approaches to control abnormal neuronal activities with electromagnetic stimulation, such as blocking the sensation of pain and suppressing hyperactive neural networks in epilepsy.
TEACHING
Lab in Neuroscience I (BIOL 373 / NEUR 301/PSYC388)
Computational Neuroscience Lab (BIOL 395L-001)
REPRESENTATIVE PUBLICATIONS
Ye H, Finding the Location of Axonal Activation by a Miniature Magnetic Coil. Front Comput Neurosci. 2022 Jun 29;16:932615. doi: 10.3389/fncom.2022.932615.
Ye H, Chen V, Hendee J. Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation. Sci Rep. 2022 Jul 15;12(1):12131. doi: 10.1038/s41598-022-16494-8.
Domacena J, Ruan J, Ye H. Improving suction technology for nerve activity recording. J Neurosci Methods. 2022 Jan 1;365:109401. doi: 10.1016/j.jneumeth.2021.109401.
Ye H, Barrett L. Somatic inhibition by microscopic magnetic stimulation. Sci Rep. 2021 Jun 30;11(1):13591. doi: 10.1038/s41598-021-93114-x. PubMed PMID: 34193906; PubMed Central PMCID: PMC8245477.
Skach J, Conway C, Barrett L, Ye H. Axonal blockage with microscopic magnetic stimulation. Sci Rep. 2020 Oct 22;10(1):18030. doi: 10.1038/s41598-020-74891-3. PubMed PMID: 33093520; PubMed Central PMCID: PMC7582966.
Ye H, Chen VC, Helon J, Apostolopoulos N. Focal Suppression of Epileptiform Activity in the Hippocampus by a High-frequency Magnetic Field. Neuroscience. 2020 Apr 15;432:1-14. doi: 10.1016/j.neuroscience.2020.02.018. Epub 2020 Feb 25. PubMed PMID: 32105740.
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Professor
Biomedical Engineering
Ph.D. 2005, Case Western Reserve University
Phone: 773.508.2720
Fax: 773.508.3646
E-mail: hye1@luc.edu
|
RESEARCH INTERESTS
Our lab is interested in understanding the interactions between electromagnetic waves and neurons. More specifically, we investigate the biophysical and neurological mechanisms underlying electromagnetic stimulation to the nervous system, both in physiological and pathological conditions. The tools we use include computer simulation, in vivo and in vitro (patch clamp) electrophysiology, pharmacology, and imaging. There are two goals for this research. First, it will reveal the cellular and molecular mechanisms underlying the clinical treatment of neurological diseases with electromagnetic stimulations, such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS). Second, it will drive us to develop novel engineering approaches to control abnormal neuronal activities with electromagnetic stimulation, such as blocking the sensation of pain and suppressing hyperactive neural networks in epilepsy.
TEACHING
Lab in Neuroscience I (BIOL 373 / NEUR 301/PSYC388)
Computational Neuroscience Lab (BIOL 395L-001)
REPRESENTATIVE PUBLICATIONS
Ye H, Finding the Location of Axonal Activation by a Miniature Magnetic Coil. Front Comput Neurosci. 2022 Jun 29;16:932615. doi: 10.3389/fncom.2022.932615.
Ye H, Chen V, Hendee J. Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation. Sci Rep. 2022 Jul 15;12(1):12131. doi: 10.1038/s41598-022-16494-8.
Domacena J, Ruan J, Ye H. Improving suction technology for nerve activity recording. J Neurosci Methods. 2022 Jan 1;365:109401. doi: 10.1016/j.jneumeth.2021.109401.
Ye H, Barrett L. Somatic inhibition by microscopic magnetic stimulation. Sci Rep. 2021 Jun 30;11(1):13591. doi: 10.1038/s41598-021-93114-x. PubMed PMID: 34193906; PubMed Central PMCID: PMC8245477.
Skach J, Conway C, Barrett L, Ye H. Axonal blockage with microscopic magnetic stimulation. Sci Rep. 2020 Oct 22;10(1):18030. doi: 10.1038/s41598-020-74891-3. PubMed PMID: 33093520; PubMed Central PMCID: PMC7582966.
Ye H, Chen VC, Helon J, Apostolopoulos N. Focal Suppression of Epileptiform Activity in the Hippocampus by a High-frequency Magnetic Field. Neuroscience. 2020 Apr 15;432:1-14. doi: 10.1016/j.neuroscience.2020.02.018. Epub 2020 Feb 25. PubMed PMID: 32105740.