Michael Collins, PhD

Research Interests

Mediators/mechanisms of neurodegeneration and neuroprotection.

Selected Publications

• Collins,M. A.; Neafsey,E. J.Alcohol, Excitotoxicity and Adult Brain Damage: An Experimentally Unproven Chain-of-Events Frontiers in molecular neuroscience 2016 ;9:8
• Mitchell, R.M.; Tajuddin, N.; Campbell, E.M.; Neafsey, E.J.; Collins, M.A. Ethanol preconditioning of rat cerebellar cultures targets NMDA receptors to the synapse and enhances peroxiredoxin 2 expression. Brain Research 2016; 1642; 163-169 ; :
• Collins,M. A.Alcohol abuse and docosahexaenoic acid: effects on brain circulation and neurosurvival. Brain Circulation 2015 ;1(1):63-68
• Moon,K. H.; Tajuddin,N.; Brown,J.,3rd; Neafsey,E. J.; Kim,H. Y.; Collins,M. A.Phospholipase A2, oxidative stress, and neurodegeneration in binge ethanol-treated organotypic slice cultures of developing rat brain Alcoholism, Clinical and Experimental Research 2014 ;38(1):161-169
• Tajuddin,N.; Moon,K. H.; Marshall,S. A.; Nixon,K.; Neafsey,E. J.; Kim,H. Y.; Collins,M. A.Neuroinflammation and Neurodegeneration in Adult Rat Brain from Binge Ethanol Exposure: Abrogation by Docosahexaenoic Acid PLoS ONE 2014 ;9(7):e101223
• Collins,M. A.; Tajuddin,N.; Moon,K. H.; Kim,H. Y.; Nixon,K.; Neafsey,E. J.Alcohol, phospholipase A2-associated neuroinflammation, and omega3 docosahexaenoic acid protection Molecular neurobiology 2014 ;50(1):239-245
• Tajuddin,N. F.; Przybycien-Szymanska,M. M.; Pak,T. R.; Neafsey,E. J.; Collins,M. A.Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation Alcohol (Fayetteville, N.Y.) 2013 ;47(1):39-45
• Collins,M. A.; Moon,K. H.; Tajuddin,N.; Neafsey,E. J.; Kim,H. Y.Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures Neurotoxicity Research 2013 ;23(1):105-110
• Piletz,J. E.; Klenotich,S.; Lee,K. S.; Zhu,Q. L.; Valente,E.; Collins,M. A.; Jones,V.; Lee,S. N.; Yangzheng,F.Putative agmatinase inhibitor for hypoxic-ischemic new born brain damage Neurotoxicity Research 2013 ;24(2):176-190
• Collins,M. A.; Neafsey,E. J.Neuroinflammatory pathways in binge alcohol-induced neuronal degeneration: oxidative stress cascade involving aquaporin, brain edema, and phospholipase A2 activation Neurotoxicity Research 2012 ;21(1):70-78
• Collins,M. A.; Neafsey,E. J.Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity. Frontiers in Bioscience 2012 ;4:1358-1367
• Neafsey,E. J.; Collins,M. A.Moderate alcohol consumption and cognitive risk NEUROPSYCHIATRIC DISEASE AND TREATMENT 2011 ;7:465-484
• Sivaswamy,S.; Neafsey,E. J.; Collins,M. A.Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteins The European journal of neuroscience 2010 ;32(11):1800-1812
• Collins,M. A.; Neafsey,E. J.; Wang,K.; Achille,N. J.; Mitchell,R. M.; Sivaswamy,S.Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms Molecular neurobiology 2010 ;41(2-3):420-425
• Brown,J.,3rd; Achille,N.; Neafsey,E. J.; Collins,M. A.Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). Neurochemical research 2009 ;34(2):260-267
• Collins,M. A.; Neafsey,E. J.; Mukamal,K. J.; Gray,M. O.; Parks,D. A.; Das,D. K.; Korthuis,R. J.Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies Alcoholism: Clinical & Experimental Research 2009 ;33(2):206-219
• Sripathirathan,K.; Brown,J.,3rd; Neafsey,E. J.; Collins,M. A.Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo. Journal of neurotrauma 2009 ;26(2):261-273
• Mitchell,R. M.; Neafsey,E. J.; Collins,M. A.Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro. Journal of neurochemistry 2009 ;111(2):580-588
• Wehrmacher,W. H.; Messmore,H. L.; Collins,M.Alcohol consumption: benefit versus peril Comprehensive therapy 2008 ;34(3-4):166-170
• Collins,M.; Wehrmacher,W. H.; Messmore,H. L.Wine, beer, and spirits metabolism Comprehensive therapy 2008 ;34(3-4):177-182
• Storch,A.; Hwang,Y. I.; Gearhart,D. A.; Beach,J. W.; Neafsey,E. J.; Collins,M. A.; Schwarz,J.Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry 2004 ;89(3):685-694
• Collins,M. A.Tetrahydropapaveroline in Parkinson's disease and alcoholism: a look back in honor of Merton Sandler. Neurotoxicology 2004 ;25(1-2):117-120
• Crews,F. T.; Collins,M. A.; Dlugos,C.; Littleton,J.; Wilkins,L.; Neafsey,E. J.; Pentney,R.; Snell,L. D.; Tabakoff,B.; Zou,J.; Noronha,A.Alcohol-induced neurodegeneration: when, where and why?. Alcoholism: Clinical & Experimental Research 2004 ;28(2):350-364
• Belmadani,A.; Kumar,S.; Schipma,M.; Collins,M. A.; Neafsey,E. J.Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by moderate ethanol preconditioning. Neuroreport 2004 ;15(13):2093-2096
• Belmadani,A.; Neafsey,E. J.; Collins,M. A.Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations. Journal of neurovirology 2003 ;9(1):45-54
• Collins,M. A.Alkaloids, alcohol and Parkinson's disease Parkinsonism & related disorders 2002 ;8(6):417-422
• Collins,M. A.; Neafsey,E. J.Potential neurotoxic "agents provocateurs" in Parkinson's disease Neurotoxicology and teratology 2002 ;24(5):571-577