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Michael Collins, PhD

Professor Emeritus of Molecular Pharmacology & Neuroscience

Research Interests

Mediators/mechanisms of neurodegeneration and neuroprotection.

Publications/Research Listings

  • Collins, M. A.; Neafsey, E. J. Alcohol, Excitotoxicity and Adult Brain Damage: An Experimentally Unproven Chain-of-Events Frontiers in molecular neuroscience 2016 ;9:8
  • Mitchell, R.M.; Tajuddin, N.; Campbell, E.M.; Neafsey, E.J.; Collins, M.A. Ethanol preconditioning of rat cerebellar cultures targets NMDA receptors to the synapse and enhances peroxiredoxin 2 expression. Brain Research 2016; 1642; 163-169 ; :
  • Collins, M. A. Alcohol abuse and docosahexaenoic acid: effects on brain circulation and neurosurvival. Brain Circulation 2015 ;1(1):63-68
  • Moon, K. H.; Tajuddin, N.; Brown,J.,3rd; Neafsey, E. J.; Kim, H. Y.; Collins, M. A. Phospholipase A2, oxidative stress, and neurodegeneration in binge ethanol-treated organotypic slice cultures of developing rat brain Alcoholism, Clinical and Experimental Research 2014 ;38(1):161-169
  • Tajuddin, N.; Moon, K. H.; Marshall, S. A.; Nixon, K.; Neafsey, E. J.; Kim, H. Y.; Collins, M. A. Neuroinflammation and Neurodegeneration in Adult Rat Brain from Binge Ethanol Exposure: Abrogation by Docosahexaenoic Acid PLoS ONE 2014 ;9(7):e101223
  • Collins, M. A.; Tajuddin, N.; Moon, K. H.; Kim, H. Y.; Nixon, K.; Neafsey, E. J. Alcohol, phospholipase A2-associated neuroinflammation, and omega3 docosahexaenoic acid protection Molecular neurobiology 2014 ;50(1):239-245
  • Tajuddin, N. F.; Przybycien-Szymanska, M. M.; Pak, T. R.; Neafsey, E. J.; Collins, M. A. Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation Alcohol (Fayetteville, N.Y.) 2013 ;47(1):39-45
  • Collins, M. A.; Moon, K. H.; Tajuddin, N.; Neafsey, E. J.; Kim, H. Y. Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures Neurotoxicity Research 2013 ;23(1):105-110
  • Piletz, J. E.; Klenotich, S.; Lee, K. S.; Zhu, Q. L.; Valente, E.; Collins, M. A.; Jones, V.; Lee, S. N.; Yangzheng, F. Putative agmatinase inhibitor for hypoxic-ischemic new born brain damage Neurotoxicity Research 2013 ;24(2):176-190
  • Collins, M. A.; Neafsey, E. J. Neuroinflammatory pathways in binge alcohol-induced neuronal degeneration: oxidative stress cascade involving aquaporin, brain edema, and phospholipase A2 activation Neurotoxicity Research 2012 ;21(1):70-78
  • Collins, M. A.; Neafsey, E. J. Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity. Frontiers in Bioscience 2012 ;4:1358-1367
  • Neafsey, E. J.; Collins, M. A. Moderate alcohol consumption and cognitive risk NEUROPSYCHIATRIC DISEASE AND TREATMENT 2011 ;7:465-484
  • Sivaswamy, S.; Neafsey, E. J.; Collins, M. A. Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteins The European journal of neuroscience 2010 ;32(11):1800-1812
  • Collins, M. A.; Neafsey, E. J.; Wang, K.; Achille, N. J.; Mitchell, R. M.; Sivaswamy, S. Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms Molecular neurobiology 2010 ;41(2-3):420-425
  • Brown,J.,3rd; Achille, N.; Neafsey,E . J.; Collins, M. A. Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). Neurochemical research 2009 ;34(2):260-267
  • Collins, M. A.; Neafsey, E. J.; Mukamal, K. J.; Gray, M. O.; Parks, D. A.; Das, D. K.; Korthuis, R. J. Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies Alcoholism: Clinical & Experimental Research 2009 ;33(2):206-219
  • Sripathirathan, K.; Brown,J.,3rd; Neafsey, E. J.; Collins, M. A. Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo. Journal of neurotrauma 2009 ;26(2):261-273
  • Mitchell, R. M.; Neafsey, E. J.; Collins, M. A. Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro. Journal of neurochemistry 2009 ;111(2):580-588
  • Wehrmacher, W. H.; Messmore, H. L.; Collins, M. Alcohol consumption: benefit versus peril Comprehensive therapy 2008 ;34(3-4):166-170
  • Collins, M.; Wehrmacher, W. H.; Messmore, H. L. Wine, beer, and spirits metabolism Comprehensive therapy 2008 ;34(3-4):177-182
  • Storch, A.; Hwang, Y. I.; Gearhart, D. A.; Beach, J. W.; Neafsey, E. J.; Collins, M. A.; Schwarz, J. Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry 2004 ;89(3):685-694
  • Collins, M. A. Tetrahydropapaveroline in Parkinson's disease and alcoholism: a look back in honor of Merton Sandler. Neurotoxicology 2004 ;25(1-2):117-120
  • Crews, F. T.; Collins, M. A.; Dlugos, C.; Littleton, J.; Wilkins, L.; Neafsey, E. J.; Pentney, R.; Snell, L. D.; Tabakoff, B.; Zou, J.; Noronha, A. Alcohol-induced neurodegeneration: when, where and why?. Alcoholism: Clinical & Experimental Research 2004 ;28(2):350-364
  • Belmadani, A.; Kumar, S.; Schipma, M.; Collins, M. A.; Neafsey, E. J. Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by moderate ethanol preconditioning. Neuroreport 2004 ;15(13):2093-2096
  • Belmadani, A.; Neafsey, E. J.; Collins, M. A. Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations. Journal of neurovirology 2003 ;9(1):45-54
  • Collins, M. A. Alkaloids, alcohol and Parkinson's disease Parkinsonism & related disorders 2002 ;8(6):417-422
  • Collins, M. A.; Neafsey, E. J. Potential neurotoxic "agents provocateurs" in Parkinson's disease Neurotoxicology and teratology 2002 ;24(5):571-577