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Liang Qiao, MD

Microbiology / Immunology

Bio

  • Professor

Ongoing Research

  • We are exposed to pathogens and unharmful antigens in the environment, especially at mucosal surfaces. Our immune system is tightly regulated so that it only fights against pathogens but not against environmental unharmful antigens. This regulation controls activation of innate immune signals, the first step of immune responses. Our goal is to study how this is regulated so that we can develop approaches to treat inflammatory diseases and to induce effective immune responses against pathogens.  Our current research interests are:
  • Innate immune signal regulation and immunotherapies targeting innate immune signals
  • Mechanisms of immune regulation by probiotic commensal bacteria
  • Development of vaccines against HPV, HIV, HCV, ZIKV as well as colorectal cancer
  • Mechanisms of tumor resistance to immunotherapy

Education

  • MD, University of Lausanne, Switzerland Immunologist

Research Interests

  • Role of regulatory T cells in GVHD and tolerance

Publications/Research Listings

  • Juan Shi#, Jian Zheng#, Xiujuan Zhang#, Wanbo Tai#, Ryan Compas#, Jack Deno, Natalie Jachym, Abhishek K Verma, Gang Wang, Xiaoqing Guan, Abby E Odle, Fang Li, Stanley Perlman*, Liang Qiao* and Lanying Du*. (#Equal contribution, *Equal senior Corresponding authors). T cell-based SARS-CoV-2 spike protein vaccine provides protection without antibodies. JCI Insight, 2024 In press.
  • Gambino#, F., W. Tai#, D. Voronin, Y. Zhang, X. Zhang, J. Shi, X. Wang, N. Wang, L. Du*, and L. Qiao*. (#Equal first authors, *Equal senior and corresponding authors). A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage. Cell Reports, 2021 May 11;35(6):109107. doi: 10.1016/j.celrep.2021.109107. PMID: 33979612.
  • Liu#, H., F. Gambino#, C. Algenio, C. Wu, Y. Gao, C. Bouchard, L. Qiao*, P. Bu*, and S. Zhao*. (#Equal first authors, *Equal senior and corresponding authors). Inflammation and Oxidative Stress Induced by Lipid Peroxidation Metabolite 4-hydroxynonenal in Human Corneal Epithelial Cells. Graefes Arch Clin Exp Ophthalmol. 2020 May 22. doi: 10.1007/s00417-020-04647-2. PMID: 32445015.
  • Liu#, H., F. Gambino#, C. Algenio, C.  Algenio,  C. Bouchard, L. Qiao*, P. Bu*, and S. Zhao*.  (#Equal first authors, *Equal senior and corresponding authors). Zidovudine protects hyperosmolarity-stressed human corneal epithelial cells via antioxidant pathway. Biochem Biophys Res Commun, 2018 May 5. DOI: 10.1016/j.bbrc.2018.03.112.  PMID: 29555477.
  • Zhong, Z., Y. Zhai, P. Bu, S. Shah, and L. Qiao. Papilloma pseudovirus eradicates intestinal tumors and triples the lifespan of ApcMin/+ mice.  Nature Communications. 2017  Apr 11;8:15004. doi:10.1038/ncomms15004. PMID: 28397782.
  • Ambrecht,L.A.; Perlman,J.I.; McDonnell, J.F.; Zhai,Y.; Qiao,L.; Bu,P. Protection of retinal function by sulforaphane following retinal ischemic injury. Experimental Eye Research. 2015 July 2:138:66-69. PMID: 26142954.
  • Bu,P.; Vin,A.P.; Sethupathi,P.; Ambrecht,L.A.; Zhai,Y.; Nikolic,N.; Qiao,L.; Bouchard,C.S. Effects of activated omental cells on rat limbal corneal alkali injury. Experimental Eye Research. 2014 April: 121:143-146. PMID24582890. 
  • Zhai, Y., Z. Zhong, M. Zariffard, G. T. Spear, and L. Qiao. Bovine papillomavirus-like particles presenting conserved epitopes from membrane-proximal external region of HIV-1 gp41 induced mucodal and systemic antibodies. Vaccine, 2013 Sep 18. doi:pii: S0264-410X(13)01230-9. 10.1016/j.vaccine.2013.09.003. PMCID: PMC3881962.
  • Lyer, S.S., H. Qiong, J.R. Janczy, E.I. Elliot, Z. Zhong, A.K. Olivier, J.J. Sadler, V. Knepper-Adrian, R. Han, L. Qiao, S.C. Eisenbarth, W.M. Nauseef, S.L. Cassel, and F.S. Sutterwala. Mitochondrial cardiolipin regulates Nlrp3 inflammasome activation. Immunity. 2013 Aug 22;39(2):311-23. doi: 10.1016/j.immuni.2013.08.001. Epub 2013 Aug 15. PMCID: PMC3779285. 
  • Zhong, Z., Y. Zhai, S. Liang, Y. Mori, R. Han, F. S. Sutterwala and L. Qiao. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nature Communications. 2013 Mar 19;4:1611. doi: 10.1038/ncomms2608. PMID:23511475;  PMCID: PMC3605705.
  • Zhang, T., Y. Xu, L. Qiao, Y. Wang, X. Wu, D. Fan, Q. Peng, and X. Xu. Trivalent Human Papillomavirus (HPV) VLP vaccine covering HPV type 58 can elicit high level of humoral immunity but also induce interference among component types. Vaccine. 2010 Apr 26;28(19):3479-87. doi: 10.1016/j.vaccine.2010.02.057. Epub 2010 Mar 6.PMID:20211219.
  • Shah, S., and L. Qiao. Resting B cells expand a CD4+CD25+Foxp3+ Treg population via TGF-beta3. European Journal of Immunology, 2008 Sep;38(9):2488-98. doi: 10.1002/eji.200838201. PMID:18792402.
  • Huang, Y., S. Shah, and L. Qiao. Tumor resistance to CD8+ T cell-based therapeutic vaccination. Arch Immunol Ther Exp. 2007 Jul-Aug;55(4):205-17. Epub 2007 Jul 23. PMID: 17659376
  • Fayad, R., M.I. Brand, D. Stone, A. Keshavarzian and L. Qiao. Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells. European Journal of Immunology, 2006 Aug;36(8):2215-22.PMID:16856205.
  • Huang, Y., N. Obholzer, R. Fayad, and L. Qiao. Turning on/off tumor-specific CTL response during progressive tumor growth. Journal of Immunology, 2005 Sep 1;175(5):3110-6. PMID:16116200.
  • Huang, Y., R. Fayad, A. Smock, A.M. Ullrich, and L. Qiao. Induction of mucosal and systemic immune responses against human carcinoembryonic antigen by an oral vaccine. Cancer Research, 2005 Aug 1;65(15):6990-9. PMID:16061685.
  • Zhang, H., R. Fayad, X. Wang, D. Quinn, and L. Qiao. HIV-1 Gag-specific Immunity after Oral immunization with Papillomavirus Pseudoviruses Encoding Gag. Journal of Virology, 2004 Oct;78(19):10249-57. PMID:15367590.
  • Fayad, R., H. Zhang, D. Quinn, Y. Huang, and L. Qiao. Oral Administration with Papillomavirus Pseudovirus Encoding IL-2 Fully Restores Mucosal and Systemic Immune Responses to Vaccinations in Aged Mice. Journal of Immunology, 2004 Aug 15;173(4):2692-8. PMID:15294987.
  • Zhang, H., Y. Huang, R. Fayad, G.T. Spear, and L. Qiao. Induction of Mucosal and Systemic Neutralizing Antibodies against HIV-1 by Oral Immunization with Bovine Papillomavirus-HIV-1 gp41 Chimeric Virus-like Particles. Journal of Virology, 2004 Aug;78(15):8342-8. PMID:15254206.
  • Bu, P., A. Keshavarzian, D. Stone, J. Liu, P. Le, S. Fisher, and L. Qiao. Apoptosis: One of the mechanisms that maintains unresponsiveness of the intestinal mucosal immune system. Journal of Immunology, 2001 May 15;166(10):6399-403. PMID:11342665.
  • Shi, W., J. Liu, Y. Huang, and L. Qiao. Papillomavirus pseudovirus: A novel vaccine to induce mucosal and systemic cytotoxic T lymphocyte responses. Journal of Virology. 2001 Nov;75(21):10139-48. PMID:11581382.
  • Schreckerberger, C., P., Sethupathi, A. Kanjanahaluethai, J. Zhou, M. Muller, L. Gissmann and L. Qiao. Induction of an HPV6b L1-specific mucosal IgA response by DNA immunization. Vaccine, 2000 Sep 15;19(2-3):227-33. PMID:10930677.
  • Contreras, D., P. Krammer, R.K. Potkul, P. Bu, J. Rossi, A. Kaufmann, L. Gissmann, and L. Qiao. Cervical cancer cells induce apoptosis of CTL. Journal of Immunotherapy, 2000 Jan;23(1):67-74. PMID:10687139.
  • Shi, W., P. Bu, J. Liu, A. Polack, S. Fisher, and L. Qiao. HPV16 E7 DNA vaccine: Mutation in the ORF of E7 enhances specific CTL generation and anti-tumor activity. Journal of Virology, 1999 Sep;73(9):7877-81. PMID:10438884.