Research Focus: The Aubert lab is interested in understanding the cardiac metabolism better. To sustain repetitive contraction throughout one’s entire life, the heart has to constantly adapt its fuel utilization to match the demand. Our Research focuses on understanding the role of metabolism and substrate utilization plasticity in cardiovascular health and disease. We combine genetically engineered mouse models of heart disease with specific patient derived IPSC cardiomyocytes in order to decipher the role of specific proteins in substrate utilization.