Research Interests

Research Focus:  We are interested in intracellular calcium signals that arise outside of the traditional excitation-contraction pathway. One protein of interest is polycystin 2-an intracellular calcium channel modifier responsible for cystic kidneys, but also an important regulatory protein in the heart. A second research focus is cross-talk between organs in pathogenesis, particularly signaling mechanisms between the heart and the kidney in cardiac and renal failure. We use biochemical, electrophysiological, isolated cardiomyocyte, and in vivo rodent models to explore these issues.