Research Interests

Research focus: Our laboratory studies the molecular basis of cardiovascular disease and molecular interventions designed as therapeutic measures. Previous work in the lab has elucidated a gene network comprised of 238 genes activated or repressed by the transcription factor NF-kB. Interestingly, most of these genes are regulated by a set of only nine microRNAs (mRNAs), which can be manipulated by transfection with mimics (gain of function), and antagomirs (loss of function). This approach can be used to dissect the role of each miRNA in gene regulation, cardioprotection, and post-myocardial infarction ventricular function and remodeling.