Research Interests

Research focus: My laboratory studies how inherited mutations in genes that regulate cardiac rhythm and contractility cause disease. Our major focus is to understand how mutations affect heart cells in the cardiac atria and in cells that comprise the cardiac conduction system. We use small animal and cell culture models to study specific mutations and evaluate physiological changes and then identify cellular and molecular mechanics of disease. Some of the major tools the lab uses include whole-animal echocardiography, isolated heart 4D optical mapping, single cardiomyocyte force measurements, and computational analysis of large transcriptomics data sets.