Communication is a key underpinning to all biological life. When this signaling goes wrong, disease or pathology often results. The Kuo laboratory studies these pathways at three distinct levels: molecular, organ, and signaling between organs utilizing a combination of electrophysiology, live-cell imaging, and non-invasive in-vivo and ex-vivo methodologies.  Our research primarily focuses on the exemplar calcium-modulating protein polycystin 2 (a protein, which when mutated results in untreatable renal cysts, kidney disease and cardiac defects), as well as other calcium-modulatory targets. The laboratory is currently funded by the NIDDK.