My laboratory uses computational and experimental techniques to probe how cells function in diverse scenarios. We specifically develop and apply computational, biophysics-based tools to probe cardiac and inflammatory functions from single atoms to entire tissue. These tools include computer vision and numerical algorithms, molecular simulations, and applied mathematics as unique approaches to understanding living systems across broad time and spatial scales. These computational aims are accompanied by wet-lab experiments examining protein and cellular function via biochemical and microscopy techniques. Our interests include:
• How calcium-binding proteins selectively modulate cellular functions.
• How intracellular signaling networks are shaped by their subcellular environment