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Jiwang Zhang, MD, PhD

Professor

Cancer Biology: Radiation Oncology

Research Interests:

  • Hematopoiesis
  • Stem cell self-renewal
  • Bone marrow microenvironment
  • Cell signaling

Bio

Our laboratory is committed to understanding how the molecular signals that emerge from the bone marrow (BM) micro-environmental niche regulate normal hematopoiesis and how deregulation of such signaling is involved in the pathogenesis of hematopoietic disorders. Specifically, we have identified: 1) factors from the normal BM niche which regulate self-renewal of hematopoietic stem cells (HSCs). We want to use such factors to stimulate the expansion of HSCs in in vitro culture for the purpose of improving the success of transplantation therapy and to induce hematopoietic regeneration in conditions of BM failure; 2) factors and related signals from diseased BM which are causally involved in disease initiation, progression and/or drug-resistance. We intend to use such information to develop novel medications for the purpose of preventing the progression of pre- leukemia to leukemia, and to develop targeted therapies to combat drug-resistant cases of leukemia. We use unbiased systematic techniques such as RNA sequencing (from RT-PCR) and shRNA/Crispr screening assays in our factor identification process. We then use both in vitro culture assays and in vivo animal models to functionally verify these factors. Finally, we always seek the goal of translating our discoveries by further evaluating our findings in primary patient samples and xenograft models.

Education

  • MD, Lanzhou Medical College, China
  • PhD, Shanghai Institute of Hematology, Shanghai, China
  • Postdoctoral fellowship, Stowers Institute for Medical Research

Research Interests

  • Hematopoiesis
  • Stem cell self-renewal
  • Bone marrow microenvironment
  • Cell signaling

Publications/Research Listings

  • Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis Joshi, K; Zhang, L; Breslin, S J P; Kini, AR; Zhang, J  Journal of Experimental & Clinical Cancer Research  2022 Oct 7;41(1):294. doi: 10.1186/s13046-022-02496-x. PMID: 36203205; PMCID: PMC9540719
  • The molecular mechanism and challenge of targeting XPO1 in treatment of relapsed and refractory myeloma  Sellin, M; Berg, S; Hagen, P; Zhang, J  Translational Oncology  2022 Aug;22:101448. doi: 10.1016/j.tranon.2022.101448. Epub 2022 Jun 1. PMID: 35660848; PMCID: PMC9166471
  • Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression  Sellin, M; Mack, R; Rhodes, MC; Zhang, L; Berg, S; Joshi, K; Liu, S; Wei, W; Breslin, S J P; Larsen, P; Taylor, RE; Zhang, J  British Journal of  Cancer  2022 Jul;127(2):223-236. doi: 10.1038/s41416-022-01796-5. Epub 2022 Apr 14. PMID: 35422078; PMCID: PMC9296642
  • Mechanisms that regulate the activities of TET proteins  Joshi, K; Liu, S; Breslin, S J P; Zhang, J  Cellular and Molecular Life Sciences  2022 Jun 15;79(7):363. doi: 10.1007/s00018-022-04396-x. PMID: 35705880
  • Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice  Zhang, L; Luo, H; Ni, HM; Liu, S; Xing, H; Zhang, J; Sellin, M; Breslin, S J P; Wei, W; Denning, MF; Small, W Jr; Ding, WX; Huang, S; Zhang, J  Stem Cell Reports  2022 Jun 14;17(6):1428-1441. doi: 10.1016/j.stemcr.2022.04.009. Epub 2022 May 12. PMID: 35561683; PMCID: PMC9213819
  • The role of TBK1 in cancer pathogenesis and anticancer immunity Runde, AP; Mack, R; Breslin, S J P; Zhang J  Journal of Experimental Clinical Cancer Research  2022 Apr 9;41(1):135. doi:10.1186/s13046-022-02352-y. PMID: 35395857; PMCID: PMC8994244
  • The fetal-to-adult hematopoietic stem cell transition and its role in childhood hematopoietic malignancies  Mack, R; Zhang, L; Breslin, SJ P; Zhang, J  Stem Cell Reviews and Reports  2021 Dec;17(6):2059-2080. doi: 10.1007/s12015-021-10230-x. Epub 2021 Aug 23. PMID: 34424480; PMCID: PMC9059172
  • Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice  Sheng, Y; Ma, R; Yu, C; Wu, Q; Zhang, S; Paulsen, K; Zhang, J; Ni, H; Huang, Y; Zheng, Y; Qian, Z  Blood  2021 Feb 4;137(5):610-623. doi: 10.1182/blood.2019004688. PMID: 33538795; PMCID: PMC8215193
  • Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches Zhang, L; Mack, R; Breslin, P; Zhang, J  Journal of Hematology & Oncology  2020 Nov 23;13(1):157. doi: 10.1186/s13045-020-00994-z. PMID: 33228751; PMCID: PMC7686726
  • Tumor microenvironment-derived R-spondins enhance antitumor immunity to suppress tumor growth and sensitize for immune checkpoint blockade therapy  Tang, Y; Xu, Q; Hu, L; Yan, X; Feng, X; Yokota, A; Wang, W; Zhan, D; Krishnamurthy, D; Ochayon, DE; Wen, L; Huo, L; Zeng, H; Luo, Y; Huang, LF; Wunderlich, M; Zhang, J; Vivier, E; Zhou, J; Waggoner, SN; Huang, G  Cancer Discovery  2021 Dec 1;11(12):3142-3157. doi: 10.1158/2159-8290.CD-20-0833. PMID: 34193438; PMCID: PMC8716674

Additional Publications List