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Jonathan Rennhack, PhD

Assistant Professor

Cancer Biology

Research Interests:

  • Tumor Metastasis
  • Tumor Microenvironment
  • Early Onset Disease

Bio

The Rennhack Lab is excited about understanding advanced cancers and discovering new therapeutic targets for patients with metastatic disease. We specifically focus on understanding the communication between metastatic tumor cells and the surrounding normal tissues. We have a particular interest in studying metastatic disease in early-onset cancers in young patients. To study these advanced disease states, we utilize spatial transcriptomics, next-generation sequencing, functional genomics, and both in vitro and in vivo model systems.

Rennhack Lab Website: 

Education

  • BA in Biology/Philosophy, Albion College
  • PhD in Physiology, Michigan State University
  • Postdoctoral Fellow: Dana-Farber Cancer Institute

Research Interests

  • Tumor Metastasis
  • Tumor Microenvironment
  • Early Onset Disease

Publications/Research Listings

  • Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation  Bala P*, Rennhack JP*, Aitymbayev D, Morris C, Moyer SM, Duronio GN, Doan P, Li Z, Liang X, Hornick JL, Yurgelun MB, Hahn WC, Sethi NS  Sci Adv. 2023 Mar 29;9(13):eadf0927. doi: 10.1126/sciadv.adf0927. Epub 2023 Mar 29. PMID: 36989360; PMCID: PMC10058311
  • SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization Dai C*, Rennhack JP*, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, Li J, Ilic N, Hwang J, Hong AL, Giacomelli AO, Gjoerup O, Root DE, Hahn WC  Cell Rep. 2021 Jul 27;36(4):109443. doi: 10.1016/j.celrep.2021.109443. PMID: 34320363; PMCID: PMC8350598
  • Integrated analyses of murine breast cancer models reveal critical parallels with human disease. Rennhack JP, To B, Swiatnicki M, Dulak C, Ogrodzinski MP, Zhang Y, Li C, Bylett E, Ross C, Szczepanek K, Hanrahan W, Jayatissa M, Lunt SY, Hunter K, Andrechek ER.  Nat Commun. 2019 Jul 22;10(1):3261. doi: 10.1038/s41467-019-11236-3. PMID: 31332182; PMCID: PMC6646342

Additional Publications List