Demi Jetters
Title: DNA Methylation Patterns of LINE-1 Specific to HC21p in Prostate Cancer Cells
Date: Wednesday, August 24th via Zoom at 6:00 pm Central Time (U.S. and Canada)
Project Description: Long Interspersed Nuclear Elements (LINEs) are retrotransposons. They function by making a cDNA copy, reverse-transcribing it into DNA and reinserting itself back into the genome; thereby, increasing its copy number. Sequencing of the human genome revealed that LINEs are underrepresented on the short arm of Human Chromosome 21 (HC21); however, the ones that are there, are active. The short arm of HC21, is primarily composed of heterochromatin and contains active L1s. Several studies investigate the role LINEs in cancer; specifically, their methylation patterns. These studies are typically done in euchromatic regions. Because of repetitive sequences, heterochromatin is extremely difficult to sequence. However these regions can be targeted for study since they pay an important role in chromosome function and a few genes may be concealed in them. Here we investigate DNA methylation patterns in promoter regions of six full length L1’s in the heterochromatic region of HC21. We also compare locus specific L1 methylation on the short arm (inactive) to the long (active) These are carried out in prostate cancer cells with various forms of aggression.
Time: Aug 24, 2022 05:30 PM Central Time (US and Canada)
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Meeting ID: 849 4580 2113
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Title: DNA Methylation Patterns of LINE-1 Specific to HC21p in Prostate Cancer Cells
Date: Wednesday, August 24th via Zoom at 6:00 pm Central Time (U.S. and Canada)
Project Description: Long Interspersed Nuclear Elements (LINEs) are retrotransposons. They function by making a cDNA copy, reverse-transcribing it into DNA and reinserting itself back into the genome; thereby, increasing its copy number. Sequencing of the human genome revealed that LINEs are underrepresented on the short arm of Human Chromosome 21 (HC21); however, the ones that are there, are active. The short arm of HC21, is primarily composed of heterochromatin and contains active L1s. Several studies investigate the role LINEs in cancer; specifically, their methylation patterns. These studies are typically done in euchromatic regions. Because of repetitive sequences, heterochromatin is extremely difficult to sequence. However these regions can be targeted for study since they pay an important role in chromosome function and a few genes may be concealed in them. Here we investigate DNA methylation patterns in promoter regions of six full length L1’s in the heterochromatic region of HC21. We also compare locus specific L1 methylation on the short arm (inactive) to the long (active) These are carried out in prostate cancer cells with various forms of aggression.
Time: Aug 24, 2022 05:30 PM Central Time (US and Canada)
Join Zoom Meeting
Meeting ID: 849 4580 2113
One tap mobile
+13126266799,,84945802113# US (Chicago)
+13092053325,,84945802113# US
Dial by your location
+1 312 626 6799 US (Chicago)
+1 309 205 3325 US
+1 301 715 8592 US (Washington DC)
+1 646 558 8656 US (New York)
+1 646 931 3860 US
+1 564 217 2000 US
+1 669 444 9171 US
+1 669 900 6833 US (San Jose)
+1 719 359 4580 US
+1 253 215 8782 US (Tacoma)
+1 346 248 7799 US (Houston)
+1 386 347 5053 US
Meeting ID: 849 4580 2113
Find your local number: https://luc.zoom.us/u/kkUpmtvfD