Becker, Daniel

Degrees

• Ph.D. in Chemistry, Indiana University, Bloomington, IN
• B.A. in Chemistry, Kalamazoo College, Kalamazoo, MI

Research Interests

Our research is focused on the design and synthesis of metalloenzyme inhibitors and also of serine protease and serine hydrolase inhibitors with antibiotic properties. In addition, we are interested in the synthesis and conformational dynamics of supramolecular scaffolds related to cyclotriveratrylene (CTV) with applications in host-guest chemistry. Other active research areas involve synthetic methodology including cascade reactions and metal-catalyzed functionalization reactions.

Selected Publications

Matthew Kochert, Boguslaw P. Nocek, Thahani S. Habeeb Mohammad, Elliot Gild, Kaitlyn Lovato, Tahirah K. Heath, Richard C. Holz, Kenneth W. Olsen, and Daniel P. Becker, "Atomic-Resolution 1.3 Å Crystal Structure, Inhibition by Sulfate, and Molecular Dynamics of the Bacterial Enzyme DapE", Biochemistry, 2021, in press.

Jackson T Baumgartner, Thahani S Habeeb Mohammad, Mateusz P Czub, Karolina Majorek, Xhulio Arolli, Cillian Variot, Madison Anonick, Wladek Minor, Miguel Angel Ballicora, Daniel P Becker, and Misty L Kuhn, "Gcn5-related N-acetyltransferases (GNATs) with a catalytic serine residue can play ping-pong too", Frontiers in Molecular Biosciences, 2021, in press.

Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye*, and Prakasha Kempaiah*, "Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays".  Elsevier Methods, 2021, in press.

Cory T. Reidl, Tahirah K. Heath, Iman Darwish, Rachel Torrez, Maxwell Moore, Elliot Gild, Boguslaw Nocek, Anna Starus, Richard C. Holz, Daniel P. Becker, "Indoline-6-sulfonamide Inhibitors of the Bacterial Enzyme DapE", Antibiotics, 2020, Sept. 9(9): 595, doi: 10.3390/antibiotics9090595.

Dawid Maciorowski, Samir Z. El Idrissi, Yash Gupta1, Brian J. Medernach, Michael B. Burns, Daniel P. Becker, Ravi Durvasula1, and Prakasha Kempaiah, "A Review of the Preclinical and Clinical Efficacy of Remdesivir, Hydroxychloroquine, and Lopinavir-Ritonavir Treatments Against COVID-19" SLAS Discovery (Society for Laboratory Automation and Screening), 2020. Featured article in Special Issue on Drug Discovery Targeting COVID-19. https://journals.sagepub.com/doi/pdf/10.1177/2472555220958385

Marlon R. Lutz, Jr., Sebastian Flieger, Andre Colorina, John Wozny, Narayan S. Hosmane, and Daniel P. Becker, Carborane-containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron Capture Therapy (BNCT), ChemMedChem 2020, http://dx.doi.org/10.1002/cmdc.202000470. Selected by Editors for issue Cover Art.

Daniel S. Catlin^§, Cory T. Reidl^§, Thomas R. Trzupek, Richard B. Silverman, Brian Cannon, Daniel P. Becker*, and Dali Liu*, (S)-4-Amino-5-phenoxypentanoate as a Selective Agonist of the Bacterial Transcription Factor GabR" Protein Science, 2020, http://dx.doi.org/10.1002/pro.3905. ^§These authors contributed equally.

Thahani S. Habeeb Mohammad, Cory T. Reidl, Matthias Zeller, and Daniel P. Becker, Synthesis of a Protected 2-Aminocyclobutanone as a Modular Transition State Synthon for Medicinal Chemistry, Tetrahedron Letters, 2020 61 151632, https://doi.org/10.1016/j.tetlet.2020.151632.

Mateusz P. Czub, Brian Zhang, M. Paul Chiarelli, Karolina A. Majorek, Layton Joe, Przemyslaw J. Porebski, Alina Revilla, Weiming Wu, Daniel P. Becker, Wladek Minor, and Misty L. Kuhn, “A Gcn5-related N-acetyltransferase (GNAT) that selectively acetylates polymyxin B and colistin antibiotics”, Biochemistry, 2018, 57 (51), 7011–7020, DOI: 10.1021/acs.biochem.8b00946.

Wei-Tsung Lee, Matthias Zeller, David Upp, Yuliya Politanska, Doug Steinman, Talal Al-Assil and Daniel P. Becker, “Iron(II) Complexes of an ortho-Triazacyclophane”, Acta Crystallographica Section C: Structural Chemistry 2018, C74, 1641-1649, doi/10.1107/S2053229618015255. 

Marlon R. Lutz Jr., Elizabeth Ernst, Matthias Zeller, Jacob Dudzinski, Peter Thoresen, and Daniel P. Becker, “Attempted Resolution and Racemization of Beckmann-derived CTV-Lactam and the use of Chirabite-AR to Determine Optical Purity of the Supramolecular Scaffold”, Eur. J. Org. Chem. 2018, 4639–4645, DOI: 10.1002/ejoc.201800788

T. K. Heath, M. R. Lutz Jr, C. T. Reidl, E. R. Guzman, C. A. Herbert, B. P. Nocek, R. C. Holz, K. W. Olsen, M. A. Ballicora, D. P. Becker PloS one 2018, 13, e0196010.

Nocek, C. Reidl, A. Starus, T. Heath, D. Bienvenue, J. Osipiuk, R. P. Jedrzejczak, A. Joachimiak, D. P. Becker, R. C. Holz Biochemistry (N.Y ) 2018, 57, 574.

T. Reidl, K. A. Majorek, J. Dang, M. Law, D. Tran, K. Jew, P. Chiarelli, W. Minor, M. Kuhn, D. P. Becker The FASEB Journal 2017, 31, 923.6-923.6.

R. Osner, R. C. Holz, D. P. Becker Tetrahedron Lett. 2015, 56, 5419-5423.

R. Sarsah, M. R. Lutz, K. C. Bobb, D. P. Becker Tetrahedron Lett. 2015, 56, 5390-5392.

V. Filippova, L. A. Weston, M. L. Kuhn, B. Geissler, A. M. Gehring, N. Armoush, C. T. Adkins, G. Minasov, I. Dubrovska, L. Shuvalova, J. R. Winsor, L. D. Lavis, K. J. F. Satchell, D. P. Becker, W. F. Anderson, R. J. Johnson J. Biol. Chem. 2013, 288, 10522-10535.

M. Panagopoulos, D. Steinman, A. Goncharenko, K. Geary, C. Schleisman, E. Spaargaren, M. Zeller, D. P. Becker J. Org. Chem. 2013, 78, 3532-3540.

R. S. Sarsah, M. R. Lutz, M. Zeller, D. S. Crumrine, D. P. Becker J. Org. Chem. 2013, 78, 2051-2058.

M. Gillner, D. P. Becker, R. C. Holz JBIC, J. Biol. Inorg. Chem. 2013, 18, 155-163.

R. Lutz, M. Zeller, S. R. S. Sarsah, A. Filipowicz, H. Wouters, D. P. Becker Supramol. Chem. 2012, 24, 803-809.